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doi: 10.1016/j.biopha.2022.113386

300 As mentioned earlier, H 2 O 2 expression results in dimerization and subsequent initiation of ASK1, which initiates p38 MAPK and JNK, stabilizing p53

However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice